There have been many anecdotal reports over the last couple of decades linking the acne treatment Roaccutane with depression. Last year a study showed that administration of the drug to mice caused depressive type behaviour. In a new 'test-tube' study, researchers have identified a possible mechanism for this side-effect. They believe that the action of Roaccutane may reduce the amount of the good mood neurotransmitter serotonin that's available for the nerve cells.
Our comment: This research is not conclusive, however, since teenage acne often responds well to nutritional therapy - there are often nutrient deficiencies contributing to the condition - a try nutritional therapy for at least six months before looking at drug treatment.

Title  :  13-cis-Retinoic acid alters intracellular serotonin, increases 5-HT1A receptor, and serotonin reuptake transporter levels in vitro, O'Reilly KC et al., Exp Biol Med (Maywood). 2007 Oct;232(9):1195-203

Ref: http://www.foodforthebrain.org